'Torpedo' Lou Pirlo thought his troubles might be over when he and his new girl, Delia, hopped a boxcar headed south--as far and as fast as they could get away from the hillbillies in Appalachia and the mafia killers in New York City. But trouble has a habit of sticking to Lou, and instead of finding himself on "Big Rock Candy Mountain," he's on a downbound train, last stop: the Big Easy, New Orleans, and trouble isn't all that's stuck to Lou--he got himself a werewolf bite, and now the deadliest monster hunter on Earth will stop at nothing to put this dog down.