Florence, early XVI century. Although widely considered a genius by his contemporaries, Michelangelo Buonarroti is reduced to poverty and depleted by his struggle to finish the ceiling of the Sistine Chapel. When his commissioner and head of the Della Rovere nobility Pope Julius II dies, Michelangelo becomes obsessed with sourcing the finest marble to complete his tomb. The artist's loyalty is tested when Leo X, of the rival Medici family, ascends to the papacy and charges him with a lucrative new commission: the faȧde of the San Lorenzo basilica. Forced to lie to maintain favor with both families, Michelangelo is progressively tormented by suspicion and hallucinations, leading him to ruthlessly examine his own moral and artistic failings.