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Age later : health span, life span, and the new science of longevity

Barzilai, Nir. (Author). Robino, Toni. (Added Author).

How do some people avoid the slowing down, deteriorating, and weakening that plagues many of their peers decades earlier? Are they just lucky? Or do they know something the rest of us don't? Is it possible to grow older without getting sicker? What if you could look and feel fifty through your eighties and nineties? Founder of the Institute for Aging Research at the Albert Einstein College of Medicine and one of the leading pioneers of longevity research, Dr. Nir Barzilai's life's work is tackling the challenges of aging to delay and prevent the onset of all age-related diseases including "the big four": diabetes, cancer, heart disease, and Alzheimer's. One of Dr. Barzilai's most fascinating studies features volunteers that include 750 SuperAgers-individuals who maintain active lives well into their nineties and even beyond-and, more importantly, who reached that ripe old age never having experienced cardiovascular disease, cancer, diabetes, or cognitive decline. In Age Later, Dr. Barzilai reveals the secrets his team has unlocked about SuperAgers and the scientific discoveries that show we can mimic some of their natural resistance to the aging process. This eye-opening and inspirational book will help you think of aging not as a certainty, but as a phenomenon-like many other diseases and misfortunes-that can be targeted, improved, and even cured.

Book  - 2020
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  • ISBN: 9781250230850
  • Physical Description x, 276 pages ; 24 cm
  • Edition First edition.
  • Publisher [Place of publication not identified] : [publisher not identified], 2020.

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Includes index.

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Syndetic Solutions - Table of Contents for ISBN Number 9781250230850
Age Later : Secrets of the Healthiest, Sharpest Centenarians
Age Later : Secrets of the Healthiest, Sharpest Centenarians
by Barzilai, Nir
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Table of Contents

Age Later : Secrets of the Healthiest, Sharpest Centenarians

SectionSection DescriptionPage Number
Introductionp. 1
1One Hundred Years Youngp. 9
    The Mysteries of Agingp. 13
    What Makes SuperAgers Stay Healthy?p. 17
    Studying Centenariansp. 20
    Designing a Study Without a Control Groupp. 28
    Meeting Our First AJ Centenarians and Their Offspringp. 30
    A Perfect Genome?p. 33
    Centenarians' Interactions with Their Environmentsp. 35
    Do as I Say, Not as I Dop. 44
2Why We Agep. 47
    Recent Theoriesp. 53
    The Search for Protection from Agingp. 58
    Eating Less May Lead to More Healthy Yearsp. 63
    Unlocking the Secrets in Fatp. 64
    Caloric Restriction: A Mixed Bag of Effectsp. 71
    Aging Begins Before We're Bornp. 75
    SuperAgers' Top Secretsp. 76
3Cholesterol: Is More Better?p. 79
    Unlocking Cholesterol's Longevity Secretsp. 83
    Are There Really Good Gene Mutations?p. 86
    Solving the Mystery of Helpful Gene Mutationsp. 88
    The Benefits of CETP Personifiedp. 94
    A Mutation That Adds Years to Life Span?p. 99
4Growth Hormone: Less Is Morep. 101
    Less Growth May Lead to an Exceptionally Long Lifep. 102
    Growth Hormone Clues from Our Centenariansp. 105
    Epigenetic Mechanisms Can Increase Longevityp. 111
    Making the Most of Our Findingsp. 115
    Growth Hormones Don't "Grow" Life Spanp. 118
5Unraveling the Longevity Mystery Deep Inside Our Cellsp. 121
    A Match Made on Earthp. 122
    Mitochondria's Hidden Purposep. 124
    Resilient to the Endp. 129
    A CohBar Is Bornp. 137
    Searching for Promising Peptidesp. 141
6The Quest to Prove Aging Can Be Targetedp. 145
    Choosing an Existing Drug to Prove Our Pointp. 153
    Getting the FDA on Boardp. 156
    How the TAME Study Worksp. 158
    Who's Going to Pay for All of This?p. 163
    Metformin Is the Tool, Not the Goalp. 168
7Making Eighty the New Sixtyp. 171
    The Price of Progressp. 176
    Collaboration Is the Key to Speedp. 177
    Long, Healthy Life Span Versus Immortalityp. 180
    The Gap Between Making Drugs and Making Drugs Availablep. 185
8Stop the Clockp. 187
    How Old Is Old?p. 189
    Use It or Lose Itp. 192
    Antioxidants and Hormesisp. 195
    Thriving in the Shadow of Stressp. 197
    Preventing the Loss of Muscle Mass as We Agep. 202
    Exercise Plus Metforminp. 203
    Feeding Our Longevityp. 204
    Hydrating Wiselyp. 209
    Prevent Obesityp. 210
    Nutraceuticals Are in the Worksp. 215
    The Magic Pills We've Been Wishing Forp. 218
    When We Eat Mattersp. 220
    Our DNA Has Something to Sayp. 226
    Stay Mentally Sharpp. 230
    Other Promising Practicesp. 238
    How to Decide What's Good for Youp. 242
9Bright Horizonsp. 245
    The Unparalleled Power of Omicsp. 246
    Personalized Medicinep. 250
    Advances in Early Detectionp. 252
    Pioneering Explorationsp. 253
    Reversing Cellular Agep. 256
    Genetic Engineeringp. 258
Acknowledgmentsp. 261
Indexp. 267