AMONG the many perverse diversions and delights of Jesse Kellerman's unnerving new thriller, TROUBLE (Putnam, $24.95), are his clinically detailed descriptions of all the variables that could drive a third-year medical student like Jonah Stem crazy. The sleep deprivation from putting in 16-hour days, six days a week, might do it alone. But compounding that constant assault on the nervous system are the abusive egomaniacal surgeons, the disgusting scut work on the colorectal ward and the staggering psychic misery of observing all the human suffering. That Kellerman maintains such a grimly hilarious perspective on his subject is its own twisted tribute to the survival instincts of writers who go down to the depths to entertain their readers. In Jonah's words, when he finds himself on the psych wing: "You had to laugh. If you didn't, you'd drown." As this psychologically complex story develops, it isn't the normal crush of work and study that finally pushes this sensitive hero to the limits of his mental endurance. It's a woman who calls herself Eve Jones. Jonah thought he was rescuing Eve from a violent death when he fought and killed a man he saw attacking her on a dark street on the far West Side of Manhattan. (Indeed, he has his moment of fame as a media hero: "Superdoc Battles Sicko W/ Knife.") But Eve works her way into his bloodstream like a slow-acting poison, challenging his devotion to an ex-girlfriend who suffers from a debilitating neurological disorder and wickedly manipulating Jonah's emotional neediness to satisfy her own sadistic sexual tastes. Before Jonah realizes that this pain artist means it literally when she says "I love you to death," she has taken control of his life. Jesse Kellerman Eve may be too much of a monster to pass as a credible human being, but she's a memorable character, with her mad theories on the aesthetics of pain and her genius at recognizing the wolfish impulses Jonah has repressed under his nice-guy persona. ("She knew," Jonah acknowledges. "She could divine latent rage.") Her feats of pure, guilt-free perversity also make her a wonderful foil for the amusingly clueless friends and family members against whose behavioral norms Jonah is subconsciously rebelling. "He needed to see how it felt to say no," Jonah says, when he first blows off one of his routine duty calls on his ex-girlfriend. "And now he knew: it felt O.K." But in a very short while, it will not feel O.K. at all, and Jonah can only wish he were back on the colorectal ward. Thomas H. Cook is one of the most literary of psychological-suspense authors, and sometimes, as in THE CLOUD OF UNKNOWING (Otto Penzler/Harcourt, $24), he allows his lyrical style to swamp his story. But while the suspense is minimal in this first-person account of an underachieving small-town lawyer who fears for the sanity of his gifted but unstable sister, the narrative is sustained by its thematic richness and the subtlety of its psychological portraits of tormented characters. As children, both David Sears and his older sister, Diana, were subjected to grueling intellectual drills by their father, a paranoid schizophrenic given to frightening rages when a little boy stumbles over his lessons in Greek mythology. But unlike David, who resigns himself to being the dunce of the family, Diana is every bit as brilliant as her father - and perhaps as mad. That suspicion, first raised when Diana accuses her husband of having murdered their mentally disturbed son, becomes an obsession with David when she initiates his teenage daughter into her fanciful way of thinking. Although Cook is maddeningly coy about who actually killed whom, he writes eloquently about the fears that lead people to equate intelligence with madness, suppressing the imagination and taking refuge in mediocrity. When I'm casting about for an antidote to the sugary female sleuths who solve crimes without disrupting their social calendars, Kate Shugak, the Aleut private investigator in Dana Stabenow's Alaskan mysteries, invariably comes to mind. In more than a dozen novels, Kate has demonstrated that she can shoot a rifle, butcher a moose, overhaul an engine and survive in remote regions of the Alaskan wilderness. More amazing yet, her outdoor skills don't alienate the rugged men in her life. A DEEPER SLEEP (St. Martin's Minotaur, $24.95) finds Kate under pressure from her relatives to get tough with a serial wife-killer whose luck at eluding the law has demoralized their entire village. For once, Kate's straight-arrow methods fail her, truth being an arbitrary concept in a community where local custom dictates justice. So forget all those hair-raising treks into the wild; joining the tribal council may well be the most dangerous move Kate has ever made. Meanwhile, thousands of miles away on an Indian pueblo in New Mexico, a young female agent with the Bureau of Land Management puts some muscle into a homicide case with eerie mystical overtones. Making her striking debut in Sandi Ault's WILD INDIGO (Berkley Prime Crime, $23.95), Jamaica Wild watches a man trampled in a buffalo stampede. Despite the expression of rapture she saw on his face, she refuses to accept the Tanoah tribe's judgment that his death was a suicide and doggedly pursues an investigation that strains her relationship with the "pueblo mother" who's initiating her into the Tanoah customs. Scenes of the high, dry, glittering landscape are as clean as a sun-bleached bone, and there are thrills galore when Jamaica is trapped in a flash flood that tears down the canyon walls of an ancient mountain sacred to the tribe. But Ault is no less artful at depicting the marriage customs, funeral rites and religious ceremonies that have drawn Jamaica to this tightly knit world and made her lose her heart to its people. In Kellerman's thriller, a woman works her way into his medical-student hero's bloodstream like a slow-acting poison.

At the start of Ault's strong debut, agent Jamaica Wild of the Bureau of Land Management is shocked to see Jerome Santana, a member of the Tanoah tribe of northern New Mexico, trampled to death by a herd of buffalo. It looks like suicide, but Jamaica suspects Jerome had been unwillingly drugged. A tribal elder and a child who also witnessed the fatal stampede go missing, and the authorities blame Jamaica for causing the death she tried to prevent. Jamaica combines a stubborn independent streak with an equally powerful longing to belong-a longing that finds expression in both her touching devotion to her wolf pup, Mountain, and in her warm ties to the Tanoah community and her mentor and medicine teacher, Momma Anna, Jerome's mother. Tinged with mysticism, this artfully told story should appeal to fans of Nevada Barr's National Park Service ranger Anna Pigeon as well as Tony Hillerman's Joe Leaphorn and Jim Chee series and Margaret Coel's Wyoming Wind River Reservation novels. (Jan.) (c) Copyright PWxyz, LLC. All rights reserved

Native American Jerome Santana is trampled to death by stampeding buffalo when he enters their pen. The only witness is Bureau of Land Management agent Jamaica Wild, who is studying Pueblo ways under the mentorship of Momma Anna, Jerome's mother. Soon the Tanoah Pueblo people blame Jamaica for Jerome's death, and it quickly becomes clear that she and her wolf puppy, Mountain, are marked for death by witchcraft. Jamaica must navigate her way in an unfamiliar culture to find the truth. Reviewers and readers will draw parallels between Ault's enlightening, well-researched debut, set in northern New Mexico, and the mysteries of Tony Hillerman, Nevada Barr, and Aimee and David Thurlo; this is fine because she is that good. Highly recommended for all mystery collections. Ault lives in the Rocky Mountains. (c) Copyright 2010. Library Journals LLC, a wholly owned subsidiary of Media Source, Inc. No redistribution permitted.

Jamaica Wild, a resource-protection agent for the Bureau of Land Management, fails to save Jerome Santana from being trampled by a herd of buffalo. In fact, the leadership of the Tanoah Pueblo in New Mexico blames her for starting the stampede, not to mention the fact that she was on Pueblo land during Quiet Time, when visitors aren't allowed. Jamaica's investigation to prove Santana's death was murder--freeing her from culpability--leads to an exciting mountain rescue. As she investigates, Jamaica continues to maintain close ties with Momma Anna, Santana's mother, from whom she is learning about Pueblo life. In addition to her Native American studies, Jamaica, a strong-willed yet vulnerable heroine, is raising a rambunctious wolf pup and is romantically involved with forest ranger Kerry Reed. Ault blends the traditions and ceremonies from several Pueblo cultures, immersing the reader in Pueblo life and the beauty of northern New Mexico. An enjoyable series debut for fans of Nevada Barr and Tony Hillerman. --Sue O'Brien Copyright 2006 Booklist